Title : Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme.

Pub. Date : 2003 Jun 13

PMID : 12787669






1 Functional Relationships(s)
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1 In contrast, enzyme variants carrying E-->A, E-->D or E-->Q exchanges of the ENV glutamate are catalytically almost inactive, demonstrating that this residue has a central function in catalysis. Glutamic Acid melanoma antigen Mus musculus