Title : PPARgamma ligand attenuates PDGF-induced mesangial cell proliferation: role of MAP kinase.

Pub. Date : 2003 Jul

PMID : 12787395






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the present study we examined whether peroxisome proliferator-activated receptor gamma (PPARgamma) activators/ligands, thiazolidinediones such as ciglitazone, troglitazone, and rosiglitazone, can inhibit cell proliferation by modulating individual steps in the MAPK pathway. ciglitazone peroxisome proliferator activated receptor gamma Mus musculus
2 Using ciglitazone as the model compound, the mechanism of the antiproliferative effect of PPARgamma activators on MAPK and specific cell cycle regulatory proteins were examined by Western blot analysis and transfection studies. ciglitazone peroxisome proliferator activated receptor gamma Mus musculus
3 The inhibitory effect was blocked by a peroxisome proliferator-activated receptor element (PPRE) decoy oligonucleotide, indicating that the observed effect of ciglitazone was via PPARgamma activation. ciglitazone peroxisome proliferator activated receptor gamma Mus musculus