Pub. Date : 2003 Jul
PMID : 12787395
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we examined whether peroxisome proliferator-activated receptor gamma (PPARgamma) activators/ligands, thiazolidinediones such as ciglitazone, troglitazone, and rosiglitazone, can inhibit cell proliferation by modulating individual steps in the MAPK pathway. | ciglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | Using ciglitazone as the model compound, the mechanism of the antiproliferative effect of PPARgamma activators on MAPK and specific cell cycle regulatory proteins were examined by Western blot analysis and transfection studies. | ciglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | The inhibitory effect was blocked by a peroxisome proliferator-activated receptor element (PPRE) decoy oligonucleotide, indicating that the observed effect of ciglitazone was via PPARgamma activation. | ciglitazone | peroxisome proliferator activated receptor gamma | Mus musculus |