Title : Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.

Pub. Date : 2003 May 1

PMID : 12736327






1 Functional Relationships(s)
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1 At the sigma1 receptor level, 3beta-hydroxy-5-androsten-17-one [dehydroepiandrosterone (DHEA)] and 3beta-hydroxy-5-pregnen-20-one (pregnenolone) act as agonists, whereas 4-pregnene-3,20-dione (progesterone) is an efficient antagonist. Dehydroepiandrosterone sigma non-opioid intracellular receptor 1 Mus musculus