Title : Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity.

Pub. Date : 2003 May 1

PMID : 12706121






2 Functional Relationships(s)
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1 Interestingly, while the presence of oxysterols in cell membranes significantly inhibits chemokine receptor function, this inhibitory effect does not involve alterations in receptor conformation, expression, or a direct antagonism of chemokine binding. Oxysterols C-X-C motif chemokine receptor 4 Homo sapiens
2 We propose here a novel mechanism for oxysterol-mediated inhibition of chemokine receptor function and the implications for the presence of oxysterols on immune cells. Oxysterols C-X-C motif chemokine receptor 4 Homo sapiens