Title : Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Pub. Date : 2003 Jun 13

PMID : 12676925






2 Functional Relationships(s)
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1 Moreover, Cdc25A overexpression abrogates the Chk1-mediated degradation and overcomes the doxorubicin-induced G2 arrest through dephosphorylation and activation of Cdc2/Cdk1 in a dose-dependent manner. Doxorubicin cyclin dependent kinase 1 Homo sapiens
2 Moreover, Cdc25A overexpression abrogates the Chk1-mediated degradation and overcomes the doxorubicin-induced G2 arrest through dephosphorylation and activation of Cdc2/Cdk1 in a dose-dependent manner. Doxorubicin cyclin dependent kinase 1 Homo sapiens