Title : The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.

Pub. Date : 2003 Mar 15

PMID : 12626713






3 Functional Relationships(s)
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1 We show here that both Mec1 and Tel1 regulate the checkpoint response following phleomycin treatment. Phleomycins protein kinase MEC1 Saccharomyces cerevisiae S288C
2 MEC1 is required for Rad53 phosphorylation and cell-cycle progression delay following phleomycin treatment in G1, S or G2/M phases. Phleomycins protein kinase MEC1 Saccharomyces cerevisiae S288C
3 In addition, the tel1Delta mutation enhances the mec1 defect in activation of the phleomycin-induced checkpoint pathway in S phase. Phleomycins protein kinase MEC1 Saccharomyces cerevisiae S288C