Title : Endocannabinoids induce ileitis in rats via the capsaicin receptor (VR1).

Pub. Date : 2003 Feb

PMID : 12538826






4 Functional Relationships(s)
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1 The effects of anandamide and 2-AG were significantly inhibited by pretreatment with the specific capsaicin receptor (vanilloid receptor subtype 1; VR1) antagonist capsazepine. glyceryl 2-arachidonate transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 The effects of anandamide and 2-AG were significantly inhibited by pretreatment with the specific capsaicin receptor (vanilloid receptor subtype 1; VR1) antagonist capsazepine. glyceryl 2-arachidonate transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
3 The effects of anandamide and 2-AG were significantly inhibited by pretreatment with the specific capsaicin receptor (vanilloid receptor subtype 1; VR1) antagonist capsazepine. glyceryl 2-arachidonate transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
4 These results demonstrate that the endocannabinoids anandamide and 2-AG stimulate intestinal primary sensory neurons via the capsaicin VR1 receptor to release SP, resulting in enteritis, and that endocannabinoids may mediate the inflammatory effects of toxin A. glyceryl 2-arachidonate transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus