Title : Mechanisms of cytosolic Ca2+ suppression by prostaglandin E2 receptors in rat melanotrophs.

Pub. Date : 2003 Jan

PMID : 12535167






2 Functional Relationships(s)
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1 The effects of PGE2 to suppress [Ca2+]i were mimicked by the selective EP3 agonist, ONO-AE-248, whereas three other EP agonists, ONO-DI-004 (EP1), ONO-AE1-259 (EP2) and ONO-AE1-329 (EP4), had little or no effect on [Ca2+]i. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus
2 These results suggest that PGE2 acts on EP3 receptors to suppress Ca2+ entry of rat melanotrophs by selectively inhibiting VDC channels of these cells. Dinoprostone prostaglandin E receptor 3 Rattus norvegicus