Title : Fondaparinux sodium mechanism of action: identification of specific binding to purified and human plasma-derived proteins.

Pub. Date : 2002

PMID : 12383040






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 OBJECTIVE: To investigate the in vitro binding of fondaparinux sodium to purified antithrombin III (ATIII) and other plasma proteins. Fondaparinux serpin family C member 1 Homo sapiens
2 OBJECTIVE: To investigate the in vitro binding of fondaparinux sodium to purified antithrombin III (ATIII) and other plasma proteins. Fondaparinux serpin family C member 1 Homo sapiens
3 METHODS: Fondaparinux sodium was incubated with human plasma, antithrombin-depleted plasma or purified human plasma proteins, including antithrombin, alpha1-acid glycoprotein, serum albumin and immunoglobulin. Fondaparinux serpin family C member 1 Homo sapiens
4 METHODS: Fondaparinux sodium was incubated with human plasma, antithrombin-depleted plasma or purified human plasma proteins, including antithrombin, alpha1-acid glycoprotein, serum albumin and immunoglobulin. Fondaparinux serpin family C member 1 Homo sapiens
5 RESULTS: At steady state, fondaparinux sodium at therapeutic concentrations [i.e. those attainable in the prevention (0.14 to 0.50 mg/L) and treatment (up to approximately 2 mg/L) of VTE] was extensively bound (>97%) to plasma proteins and specifically bound (>94%) to purified ATIII. Fondaparinux serpin family C member 1 Homo sapiens