Title : Sodium deficiency enhances the behavioral responses to centrally administered vasopressin in rats.

Pub. Date : 2002 Aug

PMID : 12182943






11 Functional Relationships(s)
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1 Sodium deficiency enhances the behavioral responses to centrally administered vasopressin in rats. Sodium arginine vasopressin Rattus norvegicus
2 The ability of sodium deficiency to stimulate vasopressin (VP) release was examined by determining if sodium deficiency sensitizes the animal to the behavioral disruption caused by intraventricular injections of VP. Sodium arginine vasopressin Rattus norvegicus
3 The ability of sodium deficiency to stimulate vasopressin (VP) release was examined by determining if sodium deficiency sensitizes the animal to the behavioral disruption caused by intraventricular injections of VP. Sodium arginine vasopressin Rattus norvegicus
4 The ability of sodium deficiency to stimulate vasopressin (VP) release was examined by determining if sodium deficiency sensitizes the animal to the behavioral disruption caused by intraventricular injections of VP. Sodium arginine vasopressin Rattus norvegicus
5 In sodium-replete rats, intraventricular injections of 50 ng VP on Day 1 had no effect on behavior, but this dose elicited abnormal behaviors (barrel rolls, hind-limb extensions) when administered on Day 2, indicating a sensitization phenomenon. Sodium arginine vasopressin Rattus norvegicus
6 In separate experiments, the first intraventricular injection of 50 ng VP in sodium-deficient but not in sodium-replete rats also elicited barrel rotations followed by hind-limb extension. Sodium arginine vasopressin Rattus norvegicus
7 Intraventricular injection of VP also disrupted motor behavior in sodium-replete rats that had multiple prior experiences with sodium deficiency but not in naive rats. Sodium arginine vasopressin Rattus norvegicus
8 Intraventricular injection of VP also disrupted motor behavior in sodium-replete rats that had multiple prior experiences with sodium deficiency but not in naive rats. Sodium arginine vasopressin Rattus norvegicus
9 These results show that sodium deficiency can mimic the effect of central injections of VP in sensitizing the brain to the behavioral effects of exogenous VP. Sodium arginine vasopressin Rattus norvegicus
10 These results show that sodium deficiency can mimic the effect of central injections of VP in sensitizing the brain to the behavioral effects of exogenous VP. Sodium arginine vasopressin Rattus norvegicus
11 This suggests that sodium deficiency induces the central release of VP. Sodium arginine vasopressin Rattus norvegicus