Title : A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice.

Pub. Date : 2002 Jul

PMID : 12072416






3 Functional Relationships(s)
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1 In addition, treatment of 8-Br-cGMP significantly increased PFTK1 mRNA levels, and a specific inhibitor of cGMP production, ODQ, completely blocked TRH-induced expression of PFTK1 mRNA. Cyclic GMP cyclin-dependent kinase 14 Mus musculus
2 In addition, treatment of 8-Br-cGMP significantly increased PFTK1 mRNA levels, and a specific inhibitor of cGMP production, ODQ, completely blocked TRH-induced expression of PFTK1 mRNA. Cyclic GMP cyclin-dependent kinase 14 Mus musculus
3 These findings demonstrated, for the first time, a novel pathway between a neuropeptide and a cell cycle related peptide in the brain, and PFTK1 may be a key regulator for TRH action in t he cerebellum through t he NO-cGMP pathway. Cyclic GMP cyclin-dependent kinase 14 Mus musculus