Title : Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cells.

Pub. Date : 2002 Jun 1

PMID : 12010802






3 Functional Relationships(s)
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1 The observation that chemically modified AT III that lacks heparin-binding capacity had no effect on NF-kappaB activation supports the current understanding that the inhibitory potency of AT III depends on the interaction of AT III with heparinlike cell surface glycosaminoglycans. Glycosaminoglycans serpin family C member 1 Homo sapiens
2 The observation that chemically modified AT III that lacks heparin-binding capacity had no effect on NF-kappaB activation supports the current understanding that the inhibitory potency of AT III depends on the interaction of AT III with heparinlike cell surface glycosaminoglycans. Glycosaminoglycans serpin family C member 1 Homo sapiens
3 This hypothesis was underscored by the finding that the AT III beta-isoform, known to have higher affinity for glycosaminoglycans, is more effective in preventing NF-kappaB transactivation than alpha-AT III. Glycosaminoglycans serpin family C member 1 Homo sapiens