Title : Synthesis and biological evaluation on hMC3, hMC4 and hMC5 receptors of gamma-MSH analogs substituted with L-alanine.

Pub. Date : 2002 May

PMID : 11966977






2 Functional Relationships(s)
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1 For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors. Arginine proopiomelanocortin Homo sapiens
2 This study highlights the role played by the His-Phe-Arg-Trp sequence in receptor binding and in agonist activity of gamma-MSH. Arginine proopiomelanocortin Homo sapiens