Title : Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.

Pub. Date : 2002 Apr 25

PMID : 11960485






2 Functional Relationships(s)
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1 Novel 2-benzylidene-benzofuran-3-ones were designed and synthesized to mimic flavopiridol, a well-established inhibitor of cyclin-dependent kinases (CDKs) which is currently undergoing clinical evaluation. alvocidib cyclin dependent kinase 1 Homo sapiens
2 Inhibitors of CDKs 1 and 2 that are more potent and selective than flavopiridol were obtained. alvocidib cyclin dependent kinase 1 Homo sapiens