Title : Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats.

Pub. Date : 2002 Apr

PMID : 11931695






1 Functional Relationships(s)
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1 The inhibitory action of histidine was enhanced significantly by thioperamide (5 microg), however, was antagonized by both alpha fluoromethylhistidine (20 microg), a selective histidine decarboxylase inhibitor and H1 ant agonist pyrilamine (2, 5 mg/kg), dose-dependently and significantly. Histidine histidine decarboxylase Rattus norvegicus