Title : Effects of dehydroepiandrosterone on rat apolipoprotein AI gene expression in the human hepatoma cell line, HepG2.

Pub. Date : 2002 Mar

PMID : 11887177






3 Functional Relationships(s)
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1 ApoAI mRNA levels, assessed by Northern blotting, were suppressed in HepG2 cells treated with DHEA (34%) (10 microg/mL) or testosterone (36%) (T, 1 microg/mL). Dehydroepiandrosterone apolipoprotein A1 Homo sapiens
2 Estradiol alone (E2, 1 microg/mL) had relatively little effect on apoAI mRNA levels, while E2 in combination with DHEA prevented a decrease in apoAI mRNA levels compared to DHEA alone. Dehydroepiandrosterone apolipoprotein A1 Homo sapiens
3 When the androgens (ie, DHEA, T, DHT, or MTT) were combined with E2, apoAI promoter activity was suppressed. Dehydroepiandrosterone apolipoprotein A1 Homo sapiens