Title : Histidine suppresses food intake through its conversion into neuronal histamine.

Pub. Date : 2002 Jan

PMID : 11788786






4 Functional Relationships(s)
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1 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). Histidine histidine decarboxylase Rattus norvegicus
2 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). Histidine histidine decarboxylase Rattus norvegicus
3 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). Histidine histidine decarboxylase Rattus norvegicus
4 HDC activity was increased simultaneously by histidine administration compared with the controls (P < 0.05). Histidine histidine decarboxylase Rattus norvegicus