Title : Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes.

Pub. Date : 2002 Jan

PMID : 11756232






1 Functional Relationships(s)
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1 The CYP1A2 inhibitor furafylline diminished the formation of both HONH-PhIP glucuronide conjugates in a concentration-dependent manner, however, levels of 4"-HO-PhIP were unchanged, indicating that CYP1A2 does not significantly contribute to 4"-hydroxylation of PhIP. Glucuronides cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus