Title : Role of reactive oxygen species in IL-1 beta-stimulated sustained ERK activation and MMP-9 induction.

Pub. Date : 2001 Dec

PMID : 11709424






3 Functional Relationships(s)
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1 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides interleukin 1 beta Homo sapiens
2 IL-1 beta treatment stimulated superoxide production in VSM cells that was inhibited by pretreatment of cells with the superoxide scavenger N-acetyl-L-cysteine (NAC) and also by overexpression of the human manganese superoxide dismutase (MnSOD) gene. Superoxides interleukin 1 beta Homo sapiens
3 The results demonstrate that IL-1 beta-dependent MMP-9 induction is mediated by superoxide-stimulated ERK activation. Superoxides interleukin 1 beta Homo sapiens