Title : Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells.

Pub. Date : 2001 Nov

PMID : 11701752






7 Functional Relationships(s)
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1 Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
2 We have investigated mechanisms of nicotine-induced phosphorylation of extracellular signal-regulated protein kinase (p42/44 MAP kinase, ERK) and cAMP response element binding protein (CREB) in PC12h cells. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
3 We have investigated mechanisms of nicotine-induced phosphorylation of extracellular signal-regulated protein kinase (p42/44 MAP kinase, ERK) and cAMP response element binding protein (CREB) in PC12h cells. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
4 A calmodulin antagonist, a CaM kinase inhibitor, a MAP kinase kinase inhibitor inhibited nicotine-induced ERK and CREB phosphorylation. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
5 The time course of the phosphorylation of CREB induced by nicotine was similar to that of ERK induced by nicotine. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
6 These results suggest that non-alpha7 nAChRs are involved in nicotine-induced ERK phosphorylation through CaM kinase and the Ras-MAP kinase cascade and most of the nicotine-induced CREB phosphorylation is mediated by the ERK phosphorylation in PC12h cells. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
7 These results suggest that non-alpha7 nAChRs are involved in nicotine-induced ERK phosphorylation through CaM kinase and the Ras-MAP kinase cascade and most of the nicotine-induced CREB phosphorylation is mediated by the ERK phosphorylation in PC12h cells. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus