Title : TNF-alpha enhances intracellular glucocorticoid availability.

Pub. Date : 2001 Nov 2

PMID : 11696370






1 Functional Relationships(s)
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1 We observed (i) NAD-dependent enzyme activity and mRNA for 11beta-HSD2, but not 11beta-HSD1, (ii) increasing 11beta-HSD2 activity with increasing degree of differentiation and (iii) a concentration-dependent down-regulation by TNF-alpha, phorbol myristate acetate (PMA) or glucose of activity and mRNA of 11beta-HSD2. NAD hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens