Title : Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24).

Pub. Date : 2001

PMID : 11686044






1 Functional Relationships(s)
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1 Enzymatic studies on substrate specificity of CYP27B1 revealed that 25-hydroxyl group of vitamin D3 was essential for the 1 alpha-hydroxylase activity, and 24-hydroxyl group enhanced the activity, but, 23-hydroxyl group greatly reduced the activity. Cholecalciferol cytochrome P450 family 27 subfamily B member 1 Homo sapiens