Title : Distance mapping of protein-binding sites using spin-labeled oligosaccharide ligands.

Pub. Date : 2001 Nov

PMID : 11604544






2 Functional Relationships(s)
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1 The binding of a nitroxide spin-labeled analog of N-acetyllactosamine to galectin-3, a mammalian lectin of 26 kD size, is studied to map the binding sites of this small oligosaccharide on the protein surface. N-acetyllactosamine galectin 3 Homo sapiens
2 Perturbation of intensities of cross-peaks in the (15)N heteronuclear single quantum coherence (HSQC) spectrum of full-length galectin-3 owing to the bound spin label is used qualitatively to identify protein residues proximate to the binding site for N-acetyllactosamine. N-acetyllactosamine galectin 3 Homo sapiens