Title : Mechanism of inhibition of matrix metalloproteinase-9 induction by NO in vascular smooth muscle cells.

Pub. Date : 2001 Sep

PMID : 11509539






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Stimulation of VSM cells with IL-1 beta significantly (P < 0.05) increased superoxide production, ERK activation, and MMP-9 induction. Superoxides interleukin 1 beta Homo sapiens
2 Pretreatment of VSM cells with the NO donor DETA NONOate significantly (P < 0.05) decreased IL-1 beta-stimulated superoxide generation. Superoxides interleukin 1 beta Homo sapiens
3 We conclude that NO inhibits IL-1 beta-stimulated MMP-9 induction by inhibiting superoxide generation and subsequent ERK activation. Superoxides interleukin 1 beta Homo sapiens