Title : Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells.

Pub. Date : 2001 Jun 1

PMID : 11384110






5 Functional Relationships(s)
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Protein Name
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1 ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest. Tretinoin cyclin dependent kinase 1 Homo sapiens
2 ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest. Tretinoin cyclin dependent kinase 1 Homo sapiens
3 ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK. Tretinoin cyclin dependent kinase 1 Homo sapiens
4 ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK. Tretinoin cyclin dependent kinase 1 Homo sapiens
5 We conclude that ATRA synergistically enhances docetaxel toxicity by down-regulating Bcl-2 expression and partially reverses the docetaxel-induced G2/M arrest by inhibiting docetaxel-induced cdc2 phosphorylation in a pathway that is dependent on MAPK. Tretinoin cyclin dependent kinase 1 Homo sapiens