Title : Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1.

Pub. Date : 2001 Mar

PMID : 11339506






2 Functional Relationships(s)
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1 OBJECTIVE: Evaluation of tetracycline effects on the expression of MMP-1, MMP-3, tissue inhibitor(s) of metalloproteinase-1 (TIMP-1), plasminogen activators (PA), and PA inhibitor-1, which are all involved in the ultimate regulation of MMP activity could provide new insight into how tetracyclines achieve their cartilage preserving effects. Tetracycline stromelysin-1 Bos taurus
2 Production of MMP-3 was only decreased by tetracycline (IC50 = 45.4 microM). Tetracycline stromelysin-1 Bos taurus