Title : Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction.

Pub. Date : 2001 Feb 15

PMID : 11257268






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Functional genetic variants of the MS may alter total homocysteine (tHcy) as well as folate levels which are independent risk factors for vascular disease. thcy 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
2 The influence of a common genetic polymorphism (2756A-->G, D919G) of the MS gene on plasma tHcy and folate levels and its relation to the risk of myocardial infarction (MI) in a prospective study of male physicians in the US was investigated. thcy 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
3 The MS polymorphism was associated with decreased tHcy (10.55, 9.87 and 9.57 nmol/ml for DD, DG and GG genotypes, respectively) and increased folate levels (3.95, 3.78, 7.31 ng/ml for DD, DG and GG genotypes, respectively) only among controls but not cases. thcy 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens
4 It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies. thcy 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens