Title : Minocycline inhibits the production of inducible nitric oxide synthase in articular chondrocytes.

Pub. Date : 2001 Feb

PMID : 11246672






2 Functional Relationships(s)
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1 RESULTS: Minocycline dose dependently reduced IL-1 stimulated NO production by inhibition of the mRNA expression (IC50 = 69.9 microM) and protein synthesis (IC50 = 37.11 microM) of iNOS. Minocycline nitric oxide synthase 2 Bos taurus
2 CONCLUSION: Inhibition of iNOS in articular chondrocytes may be a new mechanism by which minocycline could exert its beneficial effects in the treatment of joint diseases. Minocycline nitric oxide synthase 2 Bos taurus