Title : Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway.

Pub. Date : 2000 Dec

PMID : 11228049






4 Functional Relationships(s)
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Protein Name
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1 PD98059 inhibited activation of Erk and LY294002 repressed activation of Akt in response to IGF-I, but did not affect tyrosine phosphorylation of the IGF-IR, IRS-1, IRS-2, or Shc. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens
2 Each PD98059 and LY294002 inhibited IGF-I-dependent cell proliferation in a concentration-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens
3 In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens
4 In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin like growth factor 1 Homo sapiens