Pub. Date : 2000 Dec
PMID : 11228049
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | PD98059 inhibited activation of Erk and LY294002 repressed activation of Akt in response to IGF-I, but did not affect tyrosine phosphorylation of the IGF-IR, IRS-1, IRS-2, or Shc. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | insulin like growth factor 1 | Homo sapiens | ||
2 | Each PD98059 and LY294002 inhibited IGF-I-dependent cell proliferation in a concentration-dependent manner. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | insulin like growth factor 1 | Homo sapiens | ||
3 | In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | insulin like growth factor 1 | Homo sapiens | ||
4 | In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I-mediated neurite outgrowth; however, when both PD98059 and LY294002 were present, IGF-I-dependent NPY gene expression and neurite outgrowth were abolished completely. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | insulin like growth factor 1 | Homo sapiens |