Title : Enhanced peroxynitrite formation is associated with vascular aging.

Pub. Date : 2000 Dec 18

PMID : 11120770






2 Functional Relationships(s)
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1 This is shown to be a consequence of age-associated enhanced superoxide (.O(2)(-)) production with concomitant quenching of NO by the formation of peroxynitrite leading to nitrotyrosilation of mitochondrial manganese superoxide dismutase (MnSOD), a molecular footprint of increased peroxynitrite levels, which also increased with age. Superoxides superoxide dismutase 2 Rattus norvegicus
2 This is shown to be a consequence of age-associated enhanced superoxide (.O(2)(-)) production with concomitant quenching of NO by the formation of peroxynitrite leading to nitrotyrosilation of mitochondrial manganese superoxide dismutase (MnSOD), a molecular footprint of increased peroxynitrite levels, which also increased with age. Superoxides superoxide dismutase 2 Rattus norvegicus