Title : Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta.

Pub. Date : 2001 Mar 16

PMID : 11116148






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Based on a consensus sequence, we identified a PKB phosphorylation site (Ser(1834)) within the region of p300/CBP known to bind C/EBPbeta. Serine CREB binding protein Homo sapiens
2 Signaling by PKB and phosphorylation of Ser(1834) may play an important role in modulating interactions between p300/CBP and transcription factors and mediate effects of insulin and related growth factors on gene expression. Serine CREB binding protein Homo sapiens