Title : Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status.

Pub. Date : 2000 Dec

PMID : 11093360






1 Functional Relationships(s)
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1 Preclinically, flavopiridol is a potent inhibitor of CDKs 1, 2 and 4 in cell-free assays (IC(50)in the region of 100 nM) and tumour cell growth in vitro (typical IC(50)in the region of 100 nM). alvocidib cyclin dependent kinase 1 Homo sapiens