Title : C5a-stimulated human neutrophils use a subset of beta2 integrins to support the adhesion-dependent phase of superoxide production.

Pub. Date : 2000 Nov

PMID : 11073107






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 C5a-stimulated human neutrophils use a subset of beta2 integrins to support the adhesion-dependent phase of superoxide production. Superoxides complement C5a receptor 1 Homo sapiens
2 Isolated human polymorphonuclear neutrophils (PMN) responded to human C5a with an immediate, transient release of superoxide lasting from 0.5 to 5 min. Superoxides complement C5a receptor 1 Homo sapiens
3 This was followed by a second release of superoxide, which began at 10 min after addition of C5a, was sustained for more than 30 min, and required ICAM-1 immobilized in the wells. Superoxides complement C5a receptor 1 Homo sapiens
4 Thus, PMN treated with C5a used signals via CR3, P150/95, and alphad/beta2, but not LFA-1, to support superoxide production. Superoxides complement C5a receptor 1 Homo sapiens