Title : Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study.

Pub. Date : 2000 Sep

PMID : 10999799






5 Functional Relationships(s)
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1 We aimed to define the maximal and the minimal stimulatory ACTH dose on cortisol, aldosterone, and dehydroepiandrosterone (DHEA) in humans. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
2 We aimed to define the maximal and the minimal stimulatory ACTH dose on cortisol, aldosterone, and dehydroepiandrosterone (DHEA) in humans. Dehydroepiandrosterone proopiomelanocortin Homo sapiens
3 The DHEA deltaAUCs to all ACTH doses were significantly higher (P < 0.01) than that after placebo, showing a clear dose-response relationship (P < 0.001). Dehydroepiandrosterone proopiomelanocortin Homo sapiens
4 The DHEA response to 250.0 microg ACTH was not modified by pretreatment with 0.01, 0.03, 0.06, and 0.125 microg ACTH doses, whereas it was progressively reduced by pretreatment with 0.5, 1.0, and 25.0 microg ACTH doses (P < 0.01). Dehydroepiandrosterone proopiomelanocortin Homo sapiens
5 In conclusion, these results show that an extremely low ACTH dose is needed to stimulate adrenal steroids and, among them, DHEA seems the most sensitive to corticotropin stimulation. Dehydroepiandrosterone proopiomelanocortin Homo sapiens