Title : An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease.

Pub. Date : 2000 Jul

PMID : 10959551






3 Functional Relationships(s)
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1 The effect of nicotine on TNFalpha production in LPS stimulated THP-1 monocyte cells in-vitro was also determined. Nicotine tumor necrosis factor Homo sapiens
2 Nicotine also caused a significant reduction in TNFalpha release from THP-1 cells. Nicotine tumor necrosis factor Homo sapiens
3 The mechanism of action of nicotine does not involve increased corticosterone levels, but may be a consequence of a reduction in TNFalpha or leukotriene B4 production. Nicotine tumor necrosis factor Homo sapiens