Title : PPAR-gamma-mediated regulation of normal and malignant B lineage cells.

Pub. Date : 2000 Apr

PMID : 10818446






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PGD2 undergoes dehydration to the biologically active prostaglandin 15-deoxy-delta 12,14-PGJ2 (15d-PGJ2) that binds to the nuclear receptor known as peroxisome proliferator-activated receptor gamma (PPAR-gamma). 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
2 PGD2 undergoes dehydration to the biologically active prostaglandin 15-deoxy-delta 12,14-PGJ2 (15d-PGJ2) that binds to the nuclear receptor known as peroxisome proliferator-activated receptor gamma (PPAR-gamma). 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
3 Only PPAR-gamma agonists (i.e., thiazolidinediones) mimicked the effect of 15d-PGJ2 on B lineage cells, indicating that the mechanism by which 15d-PGJ2 negatively affects B lineage cells involves PPAR-gamma. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus
4 Only PPAR-gamma agonists (i.e., thiazolidinediones) mimicked the effect of 15d-PGJ2 on B lineage cells, indicating that the mechanism by which 15d-PGJ2 negatively affects B lineage cells involves PPAR-gamma. 15-deoxy-delta(12,14)-prostaglandin J2 peroxisome proliferator activated receptor gamma Mus musculus