Title : Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.

Pub. Date : 2000 Feb

PMID : 10666117






3 Functional Relationships(s)
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1 Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production. Superoxides interleukin 1 beta Homo sapiens
2 Here we show that IL-1beta and platelet-derived growth factor (PDGF) stimulate superoxide production by pulmonary vascular SMC and that this effect is blocked by both FTI-277 and GGTI-298, suggesting that farnesylated and geranylgeranylated proteins are required for superoxide production. Superoxides interleukin 1 beta Homo sapiens
3 Furthermore, superoxide production by IL-1beta, PDGF factor, and constitutively activated Ras is blocked by diphenyleneiodonium, implicating NAD(P)H oxidase as the generating enzyme. Superoxides interleukin 1 beta Homo sapiens