Title : Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials.

Pub. Date : 1999

PMID : 10665481






1 Functional Relationships(s)
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1 Flavopiridol (HMR 1275, L86-8275), a flavonoid derived from an indigenous plant from India, demonstrated potent and specific in vitro inhibition of all cdks tested (cdks 1, 2, 4 and 7) with clear block in cell cycle progression at the G1/S and G2/M boundaries. alvocidib cyclin dependent kinase 1 Homo sapiens