Title : Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2'-deoxyadenosine, 2'-deoxyguanosine and their analogs.

Pub. Date : 1999 Nov

PMID : 10575360






2 Functional Relationships(s)
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Protein Name
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1 Human dCK catalysed the phosphorylation of D- and L-enantiomers of beta-dA, beta-araA, and beta-dG with enantioselectivities favoring the unnatural enantiomer for the adenosine derivatives and the natural enantiomer for 2"-deoxyguanosine. Vidarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster
2 Similarly, D- and L-enantiomers of beta-dA, beta-araA, and beta-dG were substrates of human dGK but with different enantioselectivities compared to dCK, especially concerning beta-dA. Vidarabine Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster