Title : Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired superoxide production.

Pub. Date : 1999 Oct

PMID : 10540319






4 Functional Relationships(s)
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1 Reduced antilisterial activity of TNF-deficient bone marrow-derived macrophages is due to impaired superoxide production. Superoxides tumor necrosis factor Mus musculus
2 The LPS-inducible superoxide production of TNF/LT-alpha(-/-) BMDM was impaired. Superoxides tumor necrosis factor Mus musculus
3 Together these findings suggest that the defective host defense of TNF/LT-alpha-deficient mice against L. monocytogenes partially stems from reduced superoxide production of macrophages due to the absence of TNF and imply a function for peroxynitrite, the reaction product of NO and superoxide, in the intracellular killing of L. monocytogenes. Superoxides tumor necrosis factor Mus musculus
4 Together these findings suggest that the defective host defense of TNF/LT-alpha-deficient mice against L. monocytogenes partially stems from reduced superoxide production of macrophages due to the absence of TNF and imply a function for peroxynitrite, the reaction product of NO and superoxide, in the intracellular killing of L. monocytogenes. Superoxides tumor necrosis factor Mus musculus