Title : Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells.

Pub. Date : 1999 Nov 1

PMID : 10528214






1 Functional Relationships(s)
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1 While ERK activation is rapid and transient, peaking at 10 min, the JNK1 activation is delayed and more sustained reaching a maximum at 2 h. ERK activation was blocked by CP 118556, indicating it is regulated by a Src-like kinase, while JNK1 was inhibited by piceatannol, revealing an upstream regulation by Syk. 3,3',4,5'-tetrahydroxystilbene mitogen-activated protein kinase 8 Homo sapiens