Title : Direct inhibition of the N-methyl-D-aspartate receptor channel by high concentrations of opioids.

Pub. Date : 1999 Oct

PMID : 10519509






1 Functional Relationships(s)
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1 CONCLUSIONS: These results, together with previous findings, suggest that the low-affinity NMDA receptor antagonist activity is a common characteristic of various opioid compounds, and that the inhibition is a result of channel-block mechanisms at the site, which partially overlaps with those of Mg2+ and ketamine. Ketamine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis