Title : Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses.

Pub. Date : 1999 Sep 28

PMID : 10504268






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Chemokines bind to glycosaminoglycans on human umbilical vein endothelial cells (HUVECs) with affinities in the micromolar range: RANTES > MCP-1 > IL-8 > MIP-1alpha. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens
2 RANTES binding showed the widest discrimination between glycosaminoglycans (700-fold), whereas MIP-1alpha was the least selective. Glycosaminoglycans C-C motif chemokine ligand 5 Homo sapiens