| 1 |
33656879 | Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. | 2021 Mar 17 |
1 |
| 2 |
34662099 | Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1. | 2021 Nov 2 |
2 |
| 3 |
32681807 | P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency. | 2020 Dec 15 |
2 |
| 4 |
32744329 | Altrenogest affects the development and endocrine milieu of ovarian follicles in prepubertal and mature gilts†. | 2020 Oct 29 |
2 |
| 5 |
31933595 | CYP17A1 and Androgen-Receptor Expression in Prostate Carcinoma Tissues and Cancer Cell Lines. | 2019 Nov |
1 |
| 6 |
29283561 | Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202. | 2018 Feb 6 |
1 |
| 7 |
28684414 | Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 |
2 |
| 8 |
26526982 | Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line. | 2016 |
1 |
| 9 |
24832628 | 3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging. | 2015 |
1 |
| 10 |
23470964 | Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer. | 2013 Jul 1 |
1 |
| 11 |
24314739 | [CYP17A1 inhibitors in prostate cancer: mechanisms of action independent of the androgenic pathway]. | 2013 Oct |
1 |
| 12 |
21918127 | Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis. | 2012 Jan |
2 |
| 13 |
22024430 | Variation in 3β-hydroxysteroid dehydrogenase activity and in pregnenolone supply rate can paradoxically alter androstenedione synthesis. | 2012 Jan |
1 |
| 14 |
22155568 | Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. | 2012 Mar 5 |
1 |
| 15 |
21307141 | The human placenta expresses CYP17 and generates androgens de novo. | 2011 May |
1 |
| 16 |
21868758 | Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. | 2011 Oct 15 |
2 |
| 17 |
19850690 | Molecular mechanism for repression of 17alpha-hydroxylase expression and androstenedione production in granulosa cells. | 2009 Dec |
1 |
| 18 |
17326004 | Sexual hormones in human skin. | 2007 Feb |
1 |
| 19 |
16828825 | In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? | 2006 Oct 15 |
1 |
| 20 |
15477877 | Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk. | 2004 |
2 |
| 21 |
12573489 | Molecular dynamics of substrate complexes with hamster cytochrome P450c17 (CYP17): mechanistic approach to understanding substrate binding and activities. | 2003 Feb 17 |
2 |
| 22 |
12788891 | The human kidney is a progesterone-metabolizing and androgen-producing organ. | 2003 Jun |
1 |
| 23 |
12915666 | The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway. | 2003 Aug |
1 |
| 24 |
14504283 | CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. | 2003 Dec 5 |
3 |
| 25 |
14522586 | 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17. | 2003 Oct 15 |
1 |
| 26 |
11751282 | Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. | 2002 Jan |
1 |
| 27 |
10999829 | Bone morphogenetic protein inhibits ovarian androgen production. | 2000 Sep |
1 |
| 28 |
9467556 | Corticotropin-releasing factor inhibits luteinizing hormone-stimulated P450c17 gene expression and androgen production by isolated thecal cells of human ovarian follicles. | 1998 Feb |
1 |
| 29 |
9888582 | The molecular basis of isolated 17,20 lyase deficiency. | 1998 Aug-Nov |
2 |
| 30 |
9257124 | Novel connections between NADPH-induced lipid peroxidation and cytochrome P450 inactivation, and antioxidant and enzyme protective properties of estradiol in gonadal membranes. | 1997 Feb |
1 |
| 31 |
8623837 | The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model. | 1996 Apr |
1 |
| 32 |
8948449 | Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications. | 1995 Jun 15 |
1 |