| 1 |
35366770 | Insights into Interactions of Human Cytochrome P450 17A1: Review. | 2022 Apr 1 |
1 |
| 2 |
33656879 | Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5. | 2021 Mar 17 |
1 |
| 3 |
34662099 | Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1. | 2021 Nov 2 |
4 |
| 4 |
31369102 | Adrenal adaptation in potassium-depleted men: role of progesterone? | 2020 Nov 1 |
1 |
| 5 |
32203088 | Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders. | 2020 May |
1 |
| 6 |
30468857 | SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates. | 2019 Mar |
1 |
| 7 |
31436174 | [Synthesis and evaluation of N-alkynylaminosteroids as potential CYP450 17A1 inhibitors]. | 2019 Jun |
1 |
| 8 |
31509771 | Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone. | 2019 Dec |
3 |
| 9 |
29710837 | Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency. | 2018 Apr 29 |
1 |
| 10 |
29758981 | Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. | 2018 Jun 13 |
1 |
| 11 |
29888793 | Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step. | 2018 Jul |
2 |
| 12 |
27702589 | Electrochemistry of cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17). | 2017 Feb 5 |
1 |
| 13 |
28387522 | Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions. | 2017 May 22 |
2 |
| 14 |
28389510 | Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer. | 2017 Aug 15 |
1 |
| 15 |
28530704 | Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. | 2017 May 22 |
2 |
| 16 |
28684414 | Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. | 2017 Aug 11 |
2 |
| 17 |
24593890 | [Congenital adrenal hyperplasia due to lack of 17α-hydroxylase: a report of a new mutation in the gene CYP17A1]. | 2015 Jan |
1 |
| 18 |
25988615 | A new pregnenolone analogues as privileged scaffolds in inhibition of CYP17 hydroxylase enzyme. Synthesis and in silico molecular docking study. | 2015 Aug |
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| 19 |
26668369 | Unveiling the crucial intermediates in androgen production. | 2015 Dec 29 |
2 |
| 20 |
24671419 | Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5. | 2014 May 16 |
2 |
| 21 |
25038322 | A steroidogenic pathway for sulfonated steroids: the metabolism of pregnenolone sulfate. | 2014 Oct |
2 |
| 22 |
25251696 | New CYP17 hydroxylase inhibitors: synthesis, biological evaluation, QSAR, and molecular docking study of new pregnenolone analogs. | 2014 Dec |
2 |
| 23 |
23620596 | Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR. | 2013 Jun 7 |
2 |
| 24 |
24160919 | Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate. | 2013 Nov 6 |
1 |
| 25 |
24482578 | Clinical Evaluation of Abiraterone in the Treatment of Metastatic Prostate Cancer. | 2013 Jul 10 |
1 |
| 26 |
21918127 | Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis. | 2012 Jan |
1 |
| 27 |
20619364 | At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17. | 2011 Jan |
1 |
| 28 |
21094146 | Steroid synthesis by primary human keratinocytes; implications for skin disease. | 2011 Jan 7 |
1 |
| 29 |
21243537 | Abiraterone acetate, a novel adrenal inhibitor in metastatic castration-resistant prostate cancer. | 2011 Apr |
1 |
| 30 |
22066265 | [Screening of potential substrates or inhibitors of cytochrome P450 17A1 (CYP17A1) by electrochemical methods]. | 2011 Jul-Aug |
2 |
| 31 |
20043997 | A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase. | 2010 Apr |
1 |
| 32 |
20086173 | Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. | 2010 Feb 1 |
1 |
| 33 |
20465382 | Abiraterone acetate: a promising drug for the treatment of castration-resistant prostate cancer. | 2010 May |
1 |
| 34 |
20595043 | Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. | 2010 Jul 30 |
1 |
| 35 |
19101629 | The role of porcine cytochrome b5A and cytochrome b5B in the regulation of cytochrome P45017A1 activities. | 2009 Jan |
2 |
| 36 |
19211174 | Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. | 2009 Jul |
1 |
| 37 |
19474057 | Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World. | 2009 Dec |
1 |
| 38 |
17786540 | SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells. | 2008 Jan |
2 |
| 39 |
16595705 | Direct electrochemistry of human, bovine and porcine cytochrome P450c17. | 2006 Apr |
1 |
| 40 |
16828825 | In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action? | 2006 Oct 15 |
1 |
| 41 |
16103714 | Disorders of androgen synthesis--from cholesterol to dehydroepiandrosterone. | 2005 |
1 |
| 42 |
31627556 | [Dehydroepiandrosterone: physiological role and possibilities of use as a drug]. | 2005 Apr 15 |
1 |
| 43 |
15635496 | Overview of dehydroepiandrosterone biosynthesis. | 2004 Nov |
1 |
| 44 |
12464253 | Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme. | 2003 Jan 1 |
1 |
| 45 |
12631293 | Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase. | 2003 Mar |
1 |
| 46 |
12788891 | The human kidney is a progesterone-metabolizing and androgen-producing organ. | 2003 Jun |
2 |
| 47 |
12915666 | The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway. | 2003 Aug |
1 |
| 48 |
12949806 | CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. | 2003 Nov 1 |
1 |
| 49 |
14504283 | CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. | 2003 Dec 5 |
2 |
| 50 |
12423360 | Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17). | 2002 Nov |
3 |