Leukotrienes

arachidonate 5-lipoxygenase activating protein ; Homo sapiens







83 Article(s)
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51 16716917 Knipholone, a selective inhibitor of leukotriene metabolism. 2006 Jun 1
52 16987874 Genetic susceptibility to myocardial infarction and coronary artery disease. 2006 Oct 15 1
53 17156456 The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein. 2006 1
54 15625306 Lipopolysaccharide induces 5-lipoxygenase-activating protein gene expression in THP-1 cells via a NF-kappaB and C/EBP-mediated mechanism. 2005 May 1
55 14770184 The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. 2004 Mar 1
56 15581413 5-Lipoxygenase as a putative link between cardiovascular and psychiatric disorders. 2004 1
57 12571239 5-lipoxygenase-activating protein gene expression. Key role of CCAAT/enhancer-binding proteins (C/EBP) in constitutive and tumor necrosis factor (TNF) alpha-induced expression in THP-1 cells. 2003 Apr 18 1
58 11035107 In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade. 2000 Oct 15 1
59 10036194 Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. 1999 Feb 15 2
60 10381823 Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein in human fetal membranes throughout pregnancy and at term. 1999 Jul 1
61 9445303 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. 1998 Jan 1
62 9630716 Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Jun 15 2
63 9804170 Cyclooxygenase-2 up-regulation after FLAP transfection in human adenocarcinoma cell line HT29 cl.19A. 1998 Oct 16 3
64 9150468 Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes. 1997 May 1
65 9375956 Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells. 1997 Oct 1
66 7556168 Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes. 1995 Aug 15 1
67 7738170 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. 1995 May 2
68 7741044 Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. 1994 Nov 5
69 8049076 Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism that accompanies differentiation of peripheral blood monocytes into alveolar macrophages. 1994 Aug 3
70 8114608 The binding of leukotriene biosynthesis inhibitors to site-directed mutants of human 5-lipoxygenase-activating protein. 1994 1
71 8145039 Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils. 1994 Apr 1 1
72 8245774 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. 1993 Dec 1 1
73 8344271 5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. 1993 Jul 1 2
74 8357989 Amino acid residues of 5-lipoxygenase-activating protein critical for the binding of leukotriene biosynthesis inhibitors. 1993 Mar-Apr 1
75 8440384 5-lipoxygenase-activating protein is an arachidonate binding protein. 1993 Mar 8 1
76 1469057 A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells. 1992 Dec 2
77 1480129 Cross-species comparison of 5-lipoxygenase-activating protein. 1992 Dec 2
78 1588922 Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition. 1992 May 7
79 1635556 Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors. 1992 Jul 2
80 1857337 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. 1991 Jul 5
81 2024291 FLAP: a novel drug target for inhibiting the synthesis of leukotrienes. 1991 Feb 4
82 2174053 Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. 1990 Nov 15 7
83 2300173 Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. 1990 Jan 18 1