Phosphatidylinositols

⇄

phosphatase and tensin homolog ; Homo sapiens







94 Article(s)
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Pub. Year
#Total Relationships
51 18459885 Anaplastic ganglioglioma arising from a Lhermitte-Duclos-like lesion. Case report. 2007 Aug 1
52 15979280 Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool. 2006 Apr 1
53 16170346 Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells. 2006 Jan 26 2
54 16287065 Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation. 2006 Apr 15 1
55 16456542 PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. 2006 Feb 22 1
56 16619521 The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. 2006 Mar-Apr 2
57 15793569 Regulation of PTEN by Rho small GTPases. 2005 Apr 2
58 16291809 Diffusion-limited phase separation in eukaryotic chemotaxis. 2005 Nov 22 1
59 14729949 Suppression of PTEN expression by NF-kappa B prevents apoptosis. 2004 Feb 1
60 14764604 Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. 2004 Apr 16 1
61 15205473 Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. 2004 Oct 1
62 15313215 Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. 2004 Sep 15 1
63 12670397 Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial. 2003 Apr 2
64 12808147 Membrane-binding and activation mechanism of PTEN. 2003 Jun 24 1
65 12869565 Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. 2003 Oct 10 1
66 12878591 A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. 2003 Oct 10 1
67 12917336 PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. 2003 Sep 1
68 14623110 Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population. 2003 Nov 20 1
69 14655756 Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. 2003 Oct 1
70 11916965 Reversible inactivation of the tumor suppressor PTEN by H2O2. 2002 Jun 7 2
71 11932928 The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells. 2002 Apr 1
72 11948419 Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. 2002 Apr 4 4
73 12077256 Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. 2002 Jul 1 2
74 12140294 Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells. 2002 Sep 27 1
75 12162696 GeneBlocs are powerful tools to study and delineate signal transduction processes that regulate cell growth and transformation. 2002 Jun 2
76 12495846 PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. 2002 Dec 1
77 11035045 The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. 2001 Jan 12 1
78 11278284 Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. 2001 Apr 6 1
79 11395408 PTEN and myotubularin: novel phosphoinositide phosphatases. 2001 1
80 11418101 Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6-pentakisphosphate 3-phosphatase activity. 2001 Jun 15 1
81 11477064 The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. 2001 Sep 21 1
82 11706404 The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. 2001 Oct 1
83 10657643 The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. 2000 Feb 15 1
84 10753747 Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. 2000 Apr 6 1
85 11070083 TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. 2000 Nov 7 6
86 11156408 Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. 2000 Dec 15 1
87 10051603 Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. 1999 Mar 2 2
88 10200246 New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. 1999 Apr 13 1
89 10203785 PTEN: a tumour suppressor that functions as a phospholipid phosphatase. 1999 Apr 1
90 10417424 [PTEN: a tumor suppressor with original properties]. 1999 Jun 1
91 10555148 Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. 1999 Oct 29 1
92 10597304 The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. 1999 Nov 25 1
93 9811831 The lipid phosphatase activity of PTEN is critical for its tumor supressor function. 1998 Nov 10 3
94 9823298 The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. 1998 Nov 15 1