phosphoinositide-3,4,5-triphosphate

phosphatase and tensin homolog ; Homo sapiens







26 Article(s)
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1 33931764 TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer. 2022 Mar 1
2 33947796 Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1. 2021 May 4 2
3 34314064 A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2. 2021 Aug 1
4 32111929 Single-molecule imaging of PI(4,5)P2 and PTEN in vitro reveals a positive feedback mechanism for PTEN membrane binding. 2020 Feb 28 1
5 32974612 Harnessing PTEN's Growth Potential in Neuronal Development and Disease. 2020 1
6 31722215 The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. 2019 Nov 12 1
7 29385737 PTEN Inhibition in Human Disease Therapy. 2018 Jan 30 1
8 29447222 Kinetics of PTEN-mediated PI(3,4,5)P3 hydrolysis on solid supported membranes. 2018 5
9 29588397 Loss of PTEN promotes formation of signaling-capable clathrin-coated pits. 2018 Apr 26 3
10 29987362 A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. 2018 Nov 4
11 27716613 Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation. 2016 Nov 8 1
12 25241900 Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration. 2015 Jul 1
13 25461777 Membrane association of the PTEN tumor suppressor: neutron scattering and MD simulations reveal the structure of protein-membrane complexes. 2015 May 2
14 26284192 Focus on PTEN Regulation. 2015 1
15 24744697 Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders. 2014 1
16 24958106 Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity. 2014 Sep 15 2
17 24985344 A unified nomenclature and amino acid numbering for human PTEN. 2014 Jul 1 1
18 23442912 Defining the membrane-associated state of the PTEN tumor suppressor protein. 2013 Feb 5 1
19 23741314 Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway. 2013 2
20 21241890 Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. 2011 Jan 21 1
21 19896393 Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. 2009 Nov 20 1
22 17786934 NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN. 2007 Nov 1 1
23 16675164 Regulation of the PTEN phosphatase. 2006 Jun 7 1
24 14764604 Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. 2004 Apr 16 2
25 15249580 A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. 2004 Jul 19 1
26 12857747 Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. 2003 Sep 5 1