| 51 |
23490149 | Improving the immunostimulatory potency of diethanolamine-containing lipid A mimics. | 2013 Apr 15 |
5 |
| 52 |
23512062 | Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. | 2013 Mar 20 |
1 |
| 53 |
23745121 | Structural Modifications of Bacterial Lipopolysaccharide that Facilitate Gram-Negative Bacteria Evasion of Host Innate Immunity. | 2013 |
1 |
| 54 |
24074146 | Monophosphoryl lipid A is an lipopolysaccharide-derived Toll-like receptor 4 agonist which may improve Alzheimer's disease pathology. | 2013 Dec |
1 |
| 55 |
24688705 | Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa. | 2013 |
2 |
| 56 |
24688739 | Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian LPS sensor system. | 2013 |
1 |
| 57 |
21382909 | Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins. | 2012 Feb |
1 |
| 58 |
22337809 | Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. | 2012 Feb 14 |
1 |
| 59 |
22354914 | The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells. | 2012 Jun |
1 |
| 60 |
22433865 | Toll-like receptor activation of human cells by synthetic triacylated lipid A-like molecules. | 2012 May 11 |
2 |
| 61 |
22459966 | Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men. | 2012 Dec |
2 |
| 62 |
22707952 | Effects of Differences in Lipid A Structure on TLR4 Pro-Inflammatory Signaling and Inflammasome Activation. | 2012 |
3 |
| 63 |
22872782 | Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2. | 2012 |
1 |
| 64 |
22876888 | Recent approaches to novel antibacterials designed after LPS structure and biochemistry. | 2012 Oct |
1 |
| 65 |
23071439 | Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica. | 2012 |
1 |
| 66 |
23085233 | Lipid A 3'-O-deacylation by Salmonella outer membrane enzyme LpxR modulates the ability of lipid A to stimulate Toll-like receptor 4. | 2012 Nov 23 |
3 |
| 67 |
23209568 | Prevalence and clinical course in invasive infections with meningococcal endotoxin variants. | 2012 |
1 |
| 68 |
22025552 | Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV+ persons reverses the decrease in TLR-4-mediated TNF-α release through prolongation of MAPK pathway activation. | 2011 Dec 1 |
1 |
| 69 |
19889939 | Immunomodulatory effects of Yersinia pestis lipopolysaccharides on human macrophages. | 2010 Jan |
2 |
| 70 |
20631129 | TLR4 ligands augment antigen-specific CD8+ T lymphocyte responses elicited by a viral vaccine vector. | 2010 Oct |
1 |
| 71 |
20665199 | The lipid A receptor. | 2010 |
3 |
| 72 |
20665200 | Lipid A receptor TLR4-mediated signaling pathways. | 2010 |
2 |
| 73 |
18974037 | Discovery of new biosynthetic pathways: the lipid A story. | 2009 Apr |
1 |
| 74 |
19321453 | Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. | 2009 May 29 |
1 |
| 75 |
19390612 | Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. | 2009 Apr |
1 |
| 76 |
19648648 | Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. | 2009 Oct 2 |
2 |
| 77 |
18178854 | Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling. | 2008 Jan 15 |
4 |
| 78 |
18375521 | Aggregation behavior of an ultra-pure lipopolysaccharide that stimulates TLR-4 receptors. | 2008 Jul |
1 |
| 79 |
18656959 | Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis. | 2008 Aug 19 |
1 |
| 80 |
18720854 | [Structure and function of lipopolysaccharide lipid A in bacteria--a review]. | 2008 Jun |
1 |
| 81 |
18802645 | Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. | 2008 Sep 21 |
1 |
| 82 |
18826950 | Constitutive activation of phosphatidylinositol 3-kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-alpha release in alveolar macrophages from asymptomatic HIV-positive persons in vitro. | 2008 Nov 28 |
1 |
| 83 |
18827361 | The preparation of a lipidic endotoxin affects its biological activities. | 2008 Oct |
1 |
| 84 |
18835160 | The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics. | 2008 Oct 15 |
1 |
| 85 |
19166381 | Understanding how lipopolysaccharide impacts CD4 T-cell immunity. | 2008 |
1 |
| 86 |
17217428 | Antagonistic lipopolysaccharides block E. coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site. | 2007 May |
3 |
| 87 |
17239348 | Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI). | 2007 Mar 9 |
6 |
| 88 |
17312114 | Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells. | 2007 Mar 1 |
1 |
| 89 |
17320193 | The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood. | 2007 Apr 15 |
1 |
| 90 |
17460147 | Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2. | 2007 Jun |
2 |
| 91 |
17466419 | TLR4-dependent adjuvant activity of Neisseria meningitidis lipid A. | 2007 May 30 |
1 |
| 92 |
17502383 | Characterization of heme as activator of Toll-like receptor 4. | 2007 Jul 13 |
1 |
| 93 |
17545685 | Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4. | 2007 Aug |
1 |
| 94 |
17569868 | The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. | 2007 Jun 15 |
1 |
| 95 |
16246469 | Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells. | 2006 Feb 27 |
1 |
| 96 |
17113914 | Synthetic triacylated lipid A derivative activates antigen presenting cells via the TLR4 pathway and promotes antigen-specific responses in vivo. | 2006 |
1 |
| 97 |
15845500 | Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins. | 2005 May |
2 |
| 98 |
15949146 | Role of lipid A palmitoylation in bacterial pathogenesis. | 2005 |
2 |
| 99 |
16091033 | The lipid A palmitoyltransferase PagP: molecular mechanisms and role in bacterial pathogenesis. | 2005 Aug |
1 |
| 100 |
16109884 | HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro. | 2005 Dec |
1 |