Cholesterol

beta-secretase 1 ; Homo sapiens







22 Article(s)
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Pub. Year
#Total Relationships
1 35201266 Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1. 2022 Apr 4 3
2 33296223 Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization. 2021 Feb 1 3
3 34189821 Amyloid β production along the neuronal secretory pathway: Dangerous liaisons in the Golgi? 2021 Sep 1
4 32555166 Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1. 2020 Jun 18 2
5 28059793 Resveratrol Intervenes Cholesterol- and Isoprenoid-Mediated Amyloidogenic Processing of AβPP in Familial Alzheimer's Disease. 2017 1
6 27155148 Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. 2016 Jul 22 2
7 26096015 Cholesterol-induced astrocyte activation is associated with increased amyloid precursor protein expression and processing. 2015 Nov 1
8 23805206 The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. 2013 1
9 23951005 Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. 2013 1
10 22551668 Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. 2012 Aug 6
11 23443094 Cholesterol-dependent energy transfer between fluorescent proteins-insights into protein proximity of APP and BACE1 in different membranes in Niemann-Pick type C disease cells. 2012 Nov 26 1
12 21257714 Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis. 2011 Apr 4
13 21630010 Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels. 2011 Oct 2
14 19885829 Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. 2010 Apr 1
15 19074428 Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. 2009 Feb 6 2
16 19199871 Cholesterol in Alzheimer's disease: unresolved questions. 2009 Feb 1
17 18374657 Impact of cholesterol level upon APP and BACE proximity and APP cleavage. 2008 May 30 4
18 16303768 Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. 2006 Feb 3 1
19 16115865 Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. 2005 Nov 4 2
20 15583033 Neuronal membrane cholesterol loss enhances amyloid peptide generation. 2004 Dec 6 1
21 14501002 Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). 2003 1
22 11525745 Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. 2001 Aug 21 2